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1996 Nov;18(11):867-74. Links Obesity genes and the regulation of body fat content.Weigle DS, Kuijper JL.Department of Medicine, University of Washington School of Medicine, Seattle, USA.Physiological investigation skin moisture ananlyzer has demonstrated that the central nervous system monitors body composition and adjusts energy intake and expenditure to stabilize total adipose tissue mass. Genetic variations in the signalling molecules involved in this regulatory system account for the heritable skin moisture ananlyzer component of body fat content. The application of molecular skin moisture ananlyzer techniques to rodent models of Mendelian obesity has resulted in the characterization of five loci at which mutations produce an abnormal accumulation of body fat. The genes at these loci include agouti, which encodes a molecule that antagonizes the binding of alpha melanocyte-stimulating hormone to its receptor; fat, which encodes carboxypeptidase E; tubby, which encodes a putative phosphodiesterase; obese, which encodes a circulating satiety protein; and diabetes, which encodes the receptor for the obese gene product.
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