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This last effect is considered to be exhibited at even lower intakes of omega-3 (EPA and DHA combined) of about 1 g/day.4 Because it appears that lower heart rate variability may be used to predict an increased risk of coronary heart disease,25 mortality vitamin c and arrhythmic events, evidence that 4 g/day of EPA and DHA (about 1.5% of daily energy intake) may increase heart vitamin c rate variability in survivors of myocardial infarction is of interest.26 Heart rate variability, a noninvasive marker of autonomic nervous system function, is reduced with sympathetic predominance and other factors (including reduced baroflex sensitivity) that may vitamin c be favourably modified by omega-3 fatty acids. Dietary supplementation with fish oil enriched with EPA and DHA (up to 3-4 g omega-3/day) has also been reported to enhance systemic large-artery endothelial function as measured in male subjects with hyperlipidemia by ultrasonic vessel wall tracking.19
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