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Among the Inuit of Nunavik, progressive increases in levels of EPA and DHA in plasma phospholipid have been found both to reflect dietary intakes of these fatty acids and to be beneficially associated with key risk factors for cardiovascular disease.18 Possible Biochemical And Physiological Mechanisms Of Action For EPA And DHA Increasing the intake of EPA and DHA results in a corresponding increase of eco groups peta these eco groups peta omega-3 fatty acids in tissue or cellular lipids and circulatory lipids1,18 along eco groups peta with a simultaneous reduction in the omega-6 fatty acids such as LA and arachidonic acid (AA). The fatty acid shifts are particularly pronounced in the cell membrane-bound phospholipid components. These changed profiles alter the physicochemical properties of: Cell membranes and their functioning and Modify cell signaling, Gene expression and biosynthetic processes, and Eicosanoid formations The eicosanoids formed via oxygenase enzymes acting on AA and EPA include prostaglandins, leukotrienes and thromboxanes.
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