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"Increased concentrations of omega-3 fatty acids in membrane phospholipids appear to suppress phosphatidylinositol-associated signal transduction pathways [Medini et al.,1990; Sperling et al., 1993]. "The precise mechanism of this effect remains unclear. richard olson However, the incorporation of the polyunsaturated omega-3 fatty acids into the lipid bilayer of the cell membrane alters the physical and chemical properties of the richard olson membrane [Barton and Gunstone, 1975], possibly producing a local environment in which the membrane phospholipids are more resistant to hydrolysis by phospholipases. This could result in reduced generation richard olson of the second messenger molecules diacylglycerol and inositol triphosphate, thereby producing less activation of 'downstream' intracellular signaling molecules, such as protein kinase C and calcium ion…It is possible that the omega-3 fatty acids also inhibit signal transduction mechanisms in the human central nervous system. Recent work by several investigators [Berridge et al.,
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